Selected Recent Publications
Frei, J. C.; Wirchnianski, A. S.;Govero, J.; Vergnolle,O;Dowd, K. A.; Pierson, T. C.; Kielian, M; Girvin M. E.; Diamond, M. S.; Lai, J. R.* Engineered Dengue Virus Domain III Proteins Elicit Cross-Neutralizing Antibody Response in Mice. J.Virol. In press.
Nyakatura, E. K., Zak, S. E., Wec, A. Z., Hofmann, D., Shulenin, S., Bakken, R. R., Aman, M. J., Chandran, K., Dye, J. M., Lai, J. R.* Design and Evaluation of Bi- and Trispecific Antibodies Targeting Multiple Filovirus Glycoproteins. J. Biol. Chem. 2018, 293, 6201-6211.
Lin, T.Y.; Lai, J. R.*Interrogation of Side Chain Biases for Oligomannose Recognition in Antibody 2G12 via Structure-Guided Phage Display Libraries. Bioorg. Med. Chem, 2017, 25, 5790-5798.
Hofmann, D. H.; Zak, S. E.; Nyakatura, E. K.; Mittler, E.; Bakken, R. R.; Chandran, K.; Dye, J. M.; Lai, J. R.*Mechanistic and Fc Requirements for Inhibition of Sudan Virus Entry and In Vivo Protection by a Synthetic Antibody. Immunol. Lett., 2017, 190, 289-295.
Wec, A. Z.; Herbert, A. S.; Murin, C. D.; Nyakatura, E. K.; Abelson, D. M.; Fels, J. M.; He, S.; James, R. M.; de La Vega, M. A.; Zhu, W.; Bakken, R. R.; Goodwin, E.; Turner, H. L.; Jangra, R. K.; Zeitlin, L.; Qiu, X.; Lai, J. R.; Walker, L. M.; Ward, A. B.; Dye, J. M.*; Chandran, K.*; Bornholdt, Z. A.* Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses. Cell, 2017, 169, 878-890.
Nyakatura, E. K.; Soare, A. Y.; Lai, J. R.* Bispecific Antibodies for Viral Immunotherapy. Hum. Vaccin. Immunother., 2017, 13, 836-842.
Wec, A.Z.; Nyakatura, E. K.; Herbert, A. S.; Howell, K. A.; Holtsberg, F. W.; Bakken, R. R.; Mittler, E.; Christin, J. R.; Shulenin, S.; Jangra, R. K.; Bharrhan, S.; Kuehne, A. I.; Bornholdt, Z. A.; Flyak, A. I.; Saphire, E. O.; Crowe, J. E. Jr*, Aman, M. J.*, Dye, J. M.*, Lai, J. R.*, Chandran K.* A "Trojan horse" bispecific antibody strategy for broad protection against ebolaviruses. Science, 2016, 354, 350-354.
Frei, J. C.; Lai, J. R.* Protein and Antibody Engineering by Phage Display. Methods Enzymol., 2016, 580, 45-87.
Frei, J. C.; Nyakatura, E. K.; Zak, S. E.; Bakken, R. A.; Chandran, K.; Dye, J. M.*; Lai, J. R.* Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses. Sci. Rep., 2016, 6, 19193.
Uchime, O.; Dai, Z.; Biris, N.; Lee, D.; Sidhu, S. S.; Li, S.; Lai, J. R.*; Gavathiotis, E.* Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site. J. Biol. Chem., 2016, 291, 89-102.
Frei, J. C.; Kielian, M.; Lai, J. R.* Comprehensive Mapping of Functional Epitopes on Dengue Virus Glycoprotein E DIII for Binding to Broadly Neutralizing Antibodies 4E11 and 4E5A by Phage Display. Virology, 2015, 485, 371-382.
Liu, Y.; Higgins, C. D.; Overstreet, C. M.; Rai, K. R.; Chiorazzi, N.*; Lai, J. R.* Peptides that Bind Specifically to an Antibody form a Chronic Lymphocytic Leukemia Clone Expressing Unmutated Immunoglobulin Variable Region Genes. Mol. Med., 2013, 19, 245-252.